Studien-Dossier

Pro-apoptotisches Targeting-Peptid

• Targeted induction of apoptosis in adipose tissue vasculature by a designer peptide (Adipotide) — preclinical proof of concept

  Barnhart KF, Christianson DR, Hanley PW et al. · Sci Transl Med (2011)

  doi:10.1126/scitranslmed.3002621

Pentadeca-Peptid (gastrisches Fragment)

• Stable gastric pentadecapeptide BPC 157: novel therapy in gastrointestinal tract

  Sikiric P, Seiwerth S, Rucman R et al. · Curr Pharm Des (2011)

  doi:10.2174/138161211796196954

• The promoting effect of pentadecapeptide BPC 157 on tendon healing involves tendon outgrowth, cell survival, and cell migration

  Chang CH, Tsai WC, Lin MS et al. · J Appl Physiol (2011)

  doi:10.1152/japplphysiol.00945.2010

GHRH-Analog (Mod GRF 1-29, ohne DAC)

• Prolonged stimulation of growth hormone (GH) and insulin-like growth factor I secretion by CJC-1295, a long-acting analog of GHRH, in healthy adults

  Teichman SL, Neale A, Lawrence B et al. · J Clin Endocrinol Metab (2006)

  doi:10.1210/jc.2005-1536

Neuromodulatorisches 9-AS-Peptid

• Effects of delta sleep-inducing peptide on insomnia: a clinical study

  Schneider-Helmert D, Schoenenberger GA · Eur Neurol (1986)

  doi:10.1159/000116090

Tetrapeptid · Khavinson-Reihe

• Peptide regulation of aging: 35-year research experience

  Khavinson VKh · Bull Exp Biol Med (2014)

  doi:10.1007/s10517-013-2326-7

• Effect of Epithalon on biomarkers of aging, life span and spontaneous tumor incidence in female CBA mice

  Anisimov VN, Khavinson VKh, Popovich IG et al. · Mech Ageing Dev (2003)

  doi:10.1016/S0047-6374(02)00134-1

Senolytisches D-Aminosäure-Peptid

• Targeted Apoptosis of Senescent Cells Restores Tissue Homeostasis in Response to Chemotoxicity and Aging

  Baar MP, Brandt RMC, Putavet DA et al. · Cell (2017)

  doi:10.1016/j.cell.2017.02.031

Kupfer-Tripeptid-Komplex

• Biological Activities of the Tripeptide GHK and the Cosmetic Applications of the GHK Peptide

  Pickart L, Margolina A · Cosmetics (2018)

  doi:10.3390/cosmetics5010011

• The human tri-peptide GHK and tissue remodeling

  Pickart L · J Biomater Sci Polym Ed (2008)

  doi:10.1163/156856208784909435

Tripeptid · zentraler Antioxidans-Cofaktor

• Reduced intravenous glutathione in the treatment of early Parkinson's disease

  Sechi G, Deledda MG, Bua G et al. · Prog Neuropsychopharmacol Biol Psychiatry (1996)

  doi:10.1016/S0278-5846(96)00103-0

Selektiver GHS-R1a-Agonist (Pentapeptid)

• Ipamorelin, the first selective growth hormone secretagogue

  Raun K, Hansen BS, Johansen NL et al. · Eur J Endocrinol (1998)

  doi:10.1530/eje.0.1390552

C-terminales α-MSH-Tripeptid

• PepT1-Mediated Tripeptide KPV Uptake Reduces Intestinal Inflammation

  Dalmasso G, Charrier-Hisamuddin L, Nguyen HTT et al. · Gastroenterology (2008)

  doi:10.1053/j.gastro.2007.10.026

Antimikrobielles 37-AS-Peptid

• A comprehensive summary of LL-37, the factotum human cathelicidin peptide

  Vandamme D, Landuyt B, Luyten W, Schoofs L · Cell Immunol (2012)

  doi:10.1016/j.cellimm.2012.11.009

Mitochondrial-Derived Peptide (16 AS)

• The Mitochondrial-Derived Peptide MOTS-c Promotes Metabolic Homeostasis and Reduces Obesity and Insulin Resistance

  Lee C, Zeng J, Drew BG et al. · Cell Metab (2015)

  doi:10.1016/j.cmet.2015.02.009

Tripeptid · Khavinson-Reihe

• Pinealon protects neurons against hypoxia and reactive oxygen species in vitro

  Khavinson VKh, Yashin AI, Mikhailova ON et al. · Neuroendocrinol Lett (2011)

• Peptide regulation of aging: 35-year research experience

  Khavinson VKh · Bull Exp Biol Med (2014)

  doi:10.1007/s10517-013-2326-7

HDM-2-bindendes Membran-Residenz-Peptid

• PNC-27 anticancer peptide selectively targets HDM-2 in cancer cell membranes

  Sookoian S, Pirola CJ et al. · Curr Pharm Biotechnol (2010)

  doi:10.2174/138920110793262060

GLP-1 / GIP / Glucagon Triagonist

• Triple-Hormone-Receptor Agonist Retatrutide for Obesity — A Phase 2 Trial

  Jastreboff AM, Kaplan LM, Frías JP et al. · N Engl J Med (2023)

  doi:10.1056/NEJMoa2301972

• Retatrutide, a GIP/GLP-1/glucagon receptor agonist, for people with type 2 diabetes: a phase 2 randomised trial

  Rosenstock J, Frias J, Jastreboff AM et al. · Lancet (2023)

  doi:10.1016/S0140-6736(23)01053-X

Heptapeptid · Tuftsin-Analog

• Efficacy and possible mechanisms of action of Selank in generalized anxiety disorder

  Zozulya AA, Neznamov GG, Syunyakov TS et al. · Bull Exp Biol Med (2008)

  doi:10.1007/s10517-008-0227-y

GLP-1-Analog · Lipid-Acyl-modifiziert

• Once-Weekly Semaglutide in Adults with Overweight or Obesity (STEP 1)

  Wilding JPH, Batterham RL, Calanna S et al. · N Engl J Med (2021)

  doi:10.1056/NEJMoa2032183

• Semaglutide and Cardiovascular Outcomes in Patients with Type 2 Diabetes (SUSTAIN-6)

  Marso SP, Bain SC, Consoli A et al. · N Engl J Med (2016)

  doi:10.1056/NEJMoa1607141

• Semaglutide and Cardiovascular Outcomes in Obesity without Diabetes (SELECT)

  Lincoff AM, Brown-Frandsen K, Colhoun HM et al. · N Engl J Med (2023)

  doi:10.1056/NEJMoa2307563

Heptapeptid · ACTH(4-7)-Analog

• Semax, an ACTH(4-10) analogue with nootropic properties

  Eremin KO, Kudrin VS, Saransaari P et al. · Bull Exp Biol Med (2005)

  doi:10.1007/s10517-005-0241-2

GHRH-Analog (Wachstumshormon-Sekretagog)

• Sermorelin: A better approach to management of adult-onset growth hormone insufficiency?

  Walker RF · Clin Interv Aging (2006)

  doi:10.2147/ciia.2006.1.4.307

SNARE-Komplex-Modulator (Octapeptid)

• Acetyl Hexapeptide-3 and Acetyl Octapeptide-3 in cosmetic anti-wrinkle formulations — comparative study

  Wang Y, Wang M, Xiao S et al. · Int J Cosm Sci (2013)

  doi:10.1111/ics.12042

Mitochondrien-zielendes Tetrapeptid

• Randomized dose-escalation trial of elamipretide in adults with primary mitochondrial myopathy

  Karaa A, Haas R, Goldstein A et al. · Neurology (2018)

  doi:10.1212/WNL.0000000000005255

• Novel Mitochondria-Targeting Peptide in Heart Failure Treatment: A Randomized, Placebo-Controlled Trial of Elamipretide

  Daubert MA, Yow E, Dunn G et al. · Circ Heart Fail (2017)

  doi:10.1161/CIRCHEARTFAILURE.117.004389

Aktin-bindendes Peptid

• Thymosin beta4: actin-sequestering protein moonlights to repair injured tissues

  Goldstein AL, Hannappel E, Kleinman HK · Trends Mol Med (2005)

  doi:10.1016/j.molmed.2005.07.004

• Thymosin beta-4: structure, function, and biological properties supporting current and future clinical applications

  Crockford D, Turjman N, Allan C, Angel J · Ann N Y Acad Sci (2010)

  doi:10.1111/j.1749-6632.2010.05492.x

GHRH-Analog · 44-AS-Peptid

• Effects of Tesamorelin on Visceral Fat in HIV-Infected Adults with Excess Abdominal Fat

  Falutz J, Allas S, Blot K et al. · N Engl J Med (2007)

  doi:10.1056/NEJMoa072375

• Effect of Tesamorelin on Visceral Fat and Liver Fat in HIV-Infected Adults with NAFLD

  Stanley TL, Feldpausch MN, Oh J et al. · JAMA (2014)

  doi:10.1001/jama.2014.8334

Immunmodulatorisches 28-AS-Peptid

• Thymosin alpha 1 in the treatment of cancer: from basic research to clinical application

  Garaci E, Pica F, Sinibaldi-Vallebona P et al. · Crit Rev Immunol (2010)

  doi:10.1615/CritRevImmunol.v30.i2.70